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o Risks for methicillin-resistant Staphylococcus aureus colonization were modeled for a clinical cohort of persons living with HIV. o Forty percent were nares negative but were colonized at another anatomic site. o Lower odds for colonization were associated with recent sexual activity and use of antiretroviral therapy. o Increased odds were associated with lower income, recent hospitalization, incarceration, use of street drugs, and skin abscess. o Screening for methicillin-resistant Staphylococcus aureus at multiple anatomic sites is indicated for persons living with HIV. American journal of infection control. 2015 Apr 1;43(4):329-35.