The researchers previously reported Clostridium difficile in 20% of retail meat in Canada, which raised concerns about potential foodborne transmissibility. Here, they study the genetic diversity of C. difficile in retail meats, using a broad Canadian sampling infrastructure and 3 culture methods. They found 6.1% prevalence and indications of possible seasonality (highest prevalence in winter). Emerg Infect Dis. 2009;15(5):802-5.