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The elimination of excessive and inappropriate use of antibiotics is a factor in the drive to contain growing health care expenses. The San Diego Medical Center, University of California, has implemented strategies aimed at controlling drug usage and subsequently reducing costs. Mechanisms found to be effective without diminishing qualify of care involve expanding the role of the infection control professional (ICP) while implementing antibiotic control stratagems such as antimicrobial utilization teams, audits of use, automatic stop orders and educational efforts. American Journal of Infection Control 2000;28(1):57-65.