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A case-only study was conducted over a 24-month period. Interventions used to reduce the incidence of healthcare-associated Clostridium difficile (C. difficile) included 10% hypochlorite disinfection, soap and water hand hygiene, contact isolation for suspected and confirmed cases, educational tool for patients and visitors, daily isolation rounds, automated report functions, and standardized nursing unit isolation processes. A 66% reduction in the number of healthcare-associated C. difficile cases was achieved during the study. American Journal of Infection Control 2007;35:310-4.