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Selection for high-level resistance by chronic triclosan exposure is not universal.

These data fail to demonstrate biologically significant drug resistance in triclosan-exposed bacteria and suggest that markedly decreased triclosan susceptibility, although confirmed for E. coli, is not a universal phenomenon. Other bacteria possibly possess more susceptible targets than FabI that are highly conserved, which may govern triclosan activity. Journal of Antimicrobial Chemotherapy 2004; 53: 772-777.

Author: McBain AJ, Ledder RG, Sreenivasan P, Gilbert P

Published: 01/01/2004

Publication Type: Journal article

Publisher: Journal of Antimicrobial Chemotherapy