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Prior Environmental Contamination Increases the Risk of Acquisition of Vancomycin-Resistant Enterococci.

Patients colonized with vancomycin-resistant enterococci (VRE) frequently contaminate their environment, but the environmental role of VRE transmission remains controversial. During a 14-month study in 2 intensive care units, weekly environmental and twice-weekly patient surveillance cultures were obtained. VRE acquisition was defined as a positive culture result >48 h after admission. To determine risk factors for VRE acquisition, Cox proportional hazards models using time-dependent covariates for colonization pressure and antibiotic exposure were examined. The results led us to conclude that prior room contamination, whether measured via environmental cultures or prior room occupancy by VRE-colonized patients, was highly predictive of VRE acquisition. Increased attention to environmental disinfection is warranted. Clinical Infectious Diseases 2008; 46:678–85.

Author: Drees M, Snydman DR, Schmid CH, Barefoot L, Hansjosten K, Vue PM

Published: 01/01/2008

Publication Type: Journal article

Publisher: Clinical Infectious Diseases