International Scientific Forum on Home Hygiene

Home Hygiene & Health

The Leading Source of Scientific, Professional & Consumer Information
International Scientific Forum on Home Hygiene

Home Hygiene & Health

The Leading Source of Scientific, Professional & Consumer Information

Neonatal antibiotic treatment is a risk factor for early wheezing

To analyse the risk factors for wheezing at 12 months of age with special reference to antibiotic treatment. Participants were infants in western Sweden, which includes urban, rural, and coastal areas, who are participating in an ongoing study. Of the total birth cohort of 16 682 infants born in 2003, 50% (8176) were randomly selected. Methods Families of infants were sent an invitation to participate in the study. Respondents completed questionnaires regarding the infant and the family when the child was 6 and 12 months of age. Response rates were 68.5% at 6 months and 68.9% at 12 months. Factors significant in an initial univariate analysis were analysed in a multivariate model. Results At 12 months of age, 20.2% of infants had _1 episode of wheezing, and 5.3% had _3 episodes of wheezing during the first year of life. Overall, 4.1% received inhaled corticosteroids (ICSs). In the multivariate analysis, independent significant risk factors for “wheezing ever” and for wheezing disorder treated with ICSs were neonatal antibiotic treatment, male gender, gestational age (GA) of _37 weeks, having a mother with asthma, having a sibling with asthma or eczema and breastfeeding for _5 months. Treatment with antibiotics was more common among extremely preterm infants. Neonatal antibiotic treatment increased the risk of later wheezing in both term and preterm infants. The odds ratio (OR) for infants with a GA of _33 weeks was 2.9 (95% confidence interval: 1.8–4.7) and for infants with a GA of _37 weeks was 2.9 (95% confidence interval: 1.7– 4.9). Conclusions The authors found that treatment with antibiotics in the neonatal period is the most potent independent risk factor for wheezing treated with ICSs during the first year of life.