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Rackemann described the 'intrinsic asthma' population over 50 years ago as a unique subgroup that was characterised by onset of progressive loss of lung function beginning later in life, possibly after a respiratory infection. It has also been associated with a female predominance, aspirin-sensitive bronchospasm, and nasal polyposis. While the aetiology is not understood, the researchers propose that persistent respiratory infections play a central role in the development of intrinsic asthma. Clin Exp Allergy. 2009;39(9):1324-9. Epub 2009 Jul 23.