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Effects of chronic triclosan exposure upon the antimicrobial susceptibility of 40 ex-situ environmental and human isolates.

Triclosan (TCS) exposure of Eschenchia coli selects for tolerant clones, mutated in their enoyl-acyl carrier protein reductase. It has been inferred that this phenomenon is widespread amongst bacterial genera and might be associated with resistance to third party agents. These data suggest that selection for high level resistance by TCS exposure is not widespread and appears to be confined to certain enteric bacteria, especially E coli. Change in TCS susceptibility did not affect susceptibility towards chemically unrelated antimicrobials. It is concluded that acquired high-level TCS resistance is not a widespread phenomenon. Journal of Applied Microbiology 2006;100:1132-40.

Author: Ledder RG, Gilbert P, Willis C, McBain AJ

Published: 01/01/2006

Publication Type: Journal article

Publisher: Journal of Applied Microbiology