International Scientific Forum on Home Hygiene

Home Hygiene & Health

The Leading Source of Scientific, Professional & Consumer Information
International Scientific Forum on Home Hygiene

Home Hygiene & Health

The Leading Source of Scientific, Professional & Consumer Information

Early origins of inflammation: microbial exposures in infancy predict lower levels of C-reactive protein in adulthood.

McDade and co-workers tested the hypothesis that microbial exposures in infancy are associated with high sensitivity C-reactive protein (CRP) in adulthood using prospective data from a birth cohort in the Philippines (n = 1461). Lower birth weight was associated with increased CRP, consistent with a role for inflammation in the widely documented inverse relationship between birth weight and adult cardiovascular diseases. In addition, higher levels of microbial exposure in infancy were associated with lower CRP. These associations were independent of socioeconomic status, measures of current body fat and other health behaviours. We conclude that measures of microbial exposure and nutrition during the pre-natal and early post-natal periods are important predictors of CRP concentration in young adulthood. Proc Biol Sci. [Epub ahead of print]