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Does environmental endotoxin exposure prevent asthma?

Evidence as to whether exposure to environmental airborne endotoxin plays a protective or inducing role in the development of asthma is reviewed. Studies of endotoxin and atopy, endotoxin and asthma, and farming and asthma are considered and, in each instance, a distinction made between evidence of primary and secondary causation. Although it is plausible that bacterial endotoxin may protect against the development of asthma, there is considerable reason for caution regarding this hypothesis. Thorax. 2002;57:86-90.

Author: Douwes J, Pearce N, Heederik D

Published: 01/01/2002

Publication Type: Journal article

Publisher: Thorax