CTX-M ?-Lactamases in Escherichia coli from Community-acquired Urinary Tract Infections, Cambodia
Despite the recent global spread of CTX-M ?-lactamases in Escherichia coli isolates from community-acquired urinary tract infections (CA-UTIs), their dissemination has been little studied in developing countries. In a 2-year prospective study, the researchers documented the prevalence of extended-spectrum ?-lactamases (ESBLs) in E. coli that were responsible for CA-UTIs in Phnom-Penh, Cambodia. Ninety-three E. coli strains were included. They observed a high prevalence of resistance to amoxicillin (88.2% of strains), cotrimoxazole (75.3%), ciprofloxacin (67.7%), gentamicin (42.5%), and third-generation cephalosporins (37.7%). A total of 34 strains carried ESBLs, all of which were CTX-M type. CTX-M carriage was associated with resistance to fluoroquinolones and aminoglycosides. Using repetitive extragenic palindromic–PCR, the researchers identified 4 clusters containing 9, 8, 3, and 2 strains. The prevalence of CTX-M ?-lactamases has reached a critical level in Cambodia, which highlights the need for study of their spread in developing countries. Emerg Infect Dis. 2009;15(5):741-8.
Publication Type: Journal article