- The Immune system recognises “self” i.e our own body cells. This is important to stop it attacking our own tissues (self antigens)
- Without immune regulation, the immune system may overreact and attack our own tissues (self antigens) (B)
- This can lead to development of autoimmune diseases such as multiple sclerosis and type 1 diabetes
- OF hypothesis proposes that microbial exposure is key to building and sustaining the immune regulatory system to ensure that it does not attack our own body cells. (A)
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